HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[4-(Trifluoromethyl)phenyl]prop-2-enoic acid → 3-(4-(Trifluoromethyl)phenyl)propionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[4-(Trifluoromethyl)phenyl]prop-2-enoic acid | HCID 74940 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-(Trifluoromethyl)phenyl)propionic Acid | HCID 3588736 | — |
Reaction Steps
A solution of 4-trifluoromethylcinnamic acid (commercial available) in methanol is hydrogenated with Pd/C (5 wt %) at 2 bar until 4-trifluoromethylcinnamic acid has reacted completely. After removal of the catalyst by filtration the 4-trifluoromethylhydrocinnamic acid is further reacted in step 2 to compound 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247560B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-dfb1c3ee7b154df78a35fde35a702229 |
| Source note | uspto-grants-2012_08 |