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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 8880Generated: October 25, 2026

2-Bromo-1,1-difluoroethane → 4-[1-(2,2-Difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

https://huagongshe.com/reaction/8880

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-1,1-difluoroethaneHCID 136186—
ReactantHCID 178418884HCID 178418884—
Product4-[1-(2,2-Difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridineHCID 11196277—

Reaction Steps

The title compound, MS: m/e=262.1 (M+H+), was prepared in accordance with the general method of example 1 from 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 2-bromo-1,1-difluoro ethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07091222B2
Source datasetuspto-grants-2006_08
ORD IDord-3ee0bb3ddc264ecaac4ee315d3cd79dd
Source noteuspto-grants-2006_08