Piperidine-1-propylamine → HCID 68407389, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-aminopropylpiperidine (60 μl, 0.38 mmol) and N-(2-t-butoxycarbonylaminophenyl)-4-[2-(methylsulfonyl)thieno[3,2-d]pyrimidin-4-yl]benzamide (Method 54, 81 mg, 0.15 mmol) in N,N-dimethylacetamide was heated first to 50° C. for 23 hours and then further heated to 75° C. for a period of 16 hours. The reaction mixture was evaporated to dryness and the crude residue purified by flash chromatography, on silica (10 g), eluting with methanol/dichloromethane (0-15%) to give the title compound (23 mg, 26%); Mass Spectrum: M+H+ 587.

Provenance & Evidence