Sodium Bicarbonate → HCID 68406977, compound

Participants

Reaction Steps

t-Butyl 2-[(4-bromo-3-fluorobenzoyl)amino]phenylcarbamate (Method 63, 205 mg, 0.5 mmol), 3-pyridine boronic acid (74 mg, 0.6 mmol), tetrakis(triphenylphosphine) palladium (104 mg, 0.09 mmol), 1,2-dimethoxyethane (3 ml) and a saturated aqueous solution of sodium hydrogen carbonate (3 ml) were stirred at 80° C. under an atmosphere of argon for 48 hours. The cooled mixture was partitioned between ethyl acetate and water. The aqueous layer was removed using Varian Chem Elut column (CE1010) and the resulting solution was then concentrated under reduced pressure and purified by flash column chromatography, eluting with ethyl acetate/isohexane (25-75%), to give the title compound (186 mg, 91%). Mass Spectrum: M+H+ 408.

Provenance & Evidence