Sodium Bicarbonate → N-(2-t-butoxycarbonylaminophenyl)-4-(2-chloropyrimidin-5-yl)benzamide

Participants

Reaction Steps

N-(2-t-butoxycarbonylaminophenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (Method 13, 4.0 g, 9.12 mmol), 5-bromo-2-chloropyrimidine (1.76 g, 9.12 mmol), tetrakis(triphenylphosphine) palladium (527 mg, 0.46 mmol), 1,2-dimethoxyethane (40 ml) and a saturated aqueous solution of sodium hydrogen carbonate (40 ml) were stirred at 80° C. under an atmosphere of argon for 18 hours. The cooled mixture was concentrated under reduced pressure. The residue was then stirred with ethyl acetate for 1 hour and the resultant solid collected by suction filtration and dried to give the title compound (2.38 g; 61%); NMR Spectrum: (DMSO-d6) 1.47 (s, 9H), 7.20 (m, 2H), 7.58 (d, 2H), 8.02 (d, 2H), 8.11 (d, 2H), 8.66 (s, 1H), 9.23 (s, 2H), 10.93 (s, 1H); Mass Spectrum: M+H+-+Bu 369.

Provenance & Evidence