4-(Chloromethyl)benzoic acid → Ethyl 4-(4-(chloromethyl)benzamido)butanoate

HRID 888051노트

반응식

HRID 888051 반응식
[Cl:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1.Cl.[NH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[Cl:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[O:9])=[CH:10][CH:11]=1

참가 물질

3

반응물 2

HCID 742344-(Chloromethyl)benzoic acidHCID 126496614-Aminobutyrate ethyl hydrochloride

생성물 1

HCID 14423658Ethyl 4-(4-(chloromethyl)benzamido)butanoate

실험 절차

Ethyl 4-(4-(chloromethyl)benzamido)butanoate 13g was prepared by coupling 4-(chloromethyl)benzoic acid 24 with ethyl 4-aminobutyrate 26 according to the procedure described for the compound 13e in Example 21 (Scheme 8). The compound 13g was isolated as colorless oil in 89% yield (2.52 g). 1H NMR (400 MHz, CDCl3): δ 1.24 (3H, t, J=6.8 Hz); 1.96 (2H, quint, J=7.2 Hz); 2.44 (2H, t, J=7.2 Hz); 3.52 (2H, t, J=7.2 Hz); 4.10 (2H, q, J=6.8 Hz); 4.60 (2H, s); 6.62 (1H, broad s); 7.44 (1H, s); 7.46 (1H, s); 7.76 (1H, s); 7.78 (1H, s). MS (ESI): m/z=284.00 (M+H+).

후처리

  1. customEthyl 4-(4-(chloromethyl)benzamido)butanoate 13g was prepared

출처 및 근거

ORD 기록
ord-310c471486e8417d97f5cd391f6d52b1
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247563B2

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