HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,5-dimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepine → 5,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,5-dimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepine | HCID 57470256 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamine | HCID 67263867 | — |
Reaction Steps
5,5-Dimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepine (350 mg, 1.6 mmol) was dissolved in MeOH. The atmosphere was replaced by Argon and a catalytic amount of Pd/C was added. The atmosphere was replaced by H2 and the reaction was stirred for 72 h at RT. The Pd/C was filtered and the MeOH was removed to give 5,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247556B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-cd4f9b87df7445a38c659676f1f7613e |
| Source note | uspto-grants-2012_08 |