反应详情

温度

130 °C

Acetic anhydride (36.3 mL) was added to 4-Methoxy pyridine N-oxide (1.09 g) and the resulting solution was warmed to 130° C. and stirred overnight. After 16 h of stirring, the crude mixture was concentrated on the rotavap. 10 mL of a 1:1 MeOH—H2O solution was added and the resulting mixture was stirred overnight. After 10 h, the mixture was concentrated to a solid. The solid was recrystallized in AcCN, filtered and rinsed with ether.

1. stirringAfter 16 h of stirring
2. concentrationthe crude mixture was concentrated on the rotavap
3. addition10 mL of a 1:1 MeOH—H2O solution was added
4. stirringthe resulting mixture was stirred overnight
5. waitAfter 10 h
6. concentrationthe mixture was concentrated to a solid
7. customThe solid was recrystallized in AcCN
8. filtrationfiltered
9. washrinsed with ether