HCID 69434910, compound → HCID 965376, compound

HRID 888102Notes

Reaction equation

HRID 888102 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([N+:11]([O-])=O)=[CH:10][C:5]=2[N:4]=[C:3]1[C:14]([F:17])([F:16])[F:15]>CO.[Pd]>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([NH2:11])=[CH:10][C:5]=2[N:4]=[C:3]1[C:14]([F:16])([F:15])[F:17]

Participants

4

Reactant 1

HCID 69434910HCID 69434910, compound

Product 1

HCID 965376HCID 965376, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In an argon purged RBF was suspended 1-methyl-5-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazole (2.0 g, 8.2 mmol, 1.0 eq.) in 50 ml of MeOH. Pd/C (cat.) was added and the atmosphere was replaced by H2 (3×). The reaction was stirred for 16 h at RT at balloon pressure. The Pd was filtered off and the MeOH removed in vacuo to yield 1-methyl-2-(trifluoromethyl)-1H-benzo[d]imidazol-5-amine.

Workup

  1. filtrationThe Pd was filtered off
  2. customthe MeOH removed in vacuo

Sources & evidence

ORD record
ord-492b57740a1e49608733333bae6f0dc9
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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