Acetic Acid → 1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde

Participants

Reaction Steps

A solution of 1H-Pyrrolo[2,3-b]pyridine (10 g, 84.7 mmol) and hexamethylenetetraamine (17.8 g, 127 mmol) was heated to reflux in a solution of 33% AcOH (100 mL) for 16 h. The mixture was diluted with water (100 mL), cooled in the refrigerator, and crystallized from the solution affording 1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde as white solid. MS (ES+): 147.1 (M+H). Calc'd. for C8H6N2O—146.05.

Provenance & Evidence