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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 888108Generated: October 30, 2026

1-Methyl-4-(5-nitro-2-pentafluoroethyl-benzyl)-piperazine → 3-(4-Methyl-piperazin-1-ylmethyl)-4-pentafluoroethyl-phenylamine

https://huagongshe.com/reaction/888108

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methyl-4-(5-nitro-2-pentafluoroethyl-benzyl)-piperazineHCID 22249267—
Reactant4-Pentafluoroethyl-3-(2-pyrrolidin-1-yl-ethoxy)-phenylamineHCID 86002232—
Product3-(4-Methyl-piperazin-1-ylmethyl)-4-pentafluoroethyl-phenylamineHCID 21959484—

Reaction Steps

3-(4-Methyl-piperazin-1-ylmethyl)-4-pentafluoroethyl-phenylamine was prepared from 1-Methyl-4-(5-nitro-2-pentafluoroethyl-benzyl)-piperazine similar to that described in the preparation of 4-Pentafluoroethyl-3-(2-pyrrolidin-1-yl-ethoxy)-phenylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08247556B2
Source datasetuspto-grants-2012_08
ORD IDord-3a1cb6213d214f1f81167bac14ea3d3f
Source noteuspto-grants-2012_08