Acetic Acid → HCID 69263578, compound

Participants

Reaction Steps

To a solution of 1-Methanesulfonyl-3,3-dimethyl-6-nitro-2,3-dihydro-1H-indole (0.88 mg, 3.22 mmol) and AcOH (3.5 mL) in THF (100 mL) was added Zinc dust (14 g, 247 mmol) by small portion. The resulting mixture was stirred at RT for 2 h and was filtered over a Celite® pad. Solvent was evaporated and residue was diluted in CH2Cl2 and washed with NaOH 1M. The resulting organic layer was dried over MgSO4, filtered and concentrated in vacuo to give 1-Methanesulfonyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-ylamine.

Provenance & Evidence