n-(4-Tert-butylphenyl)-2-fluoronicotinamide → N-(4-tert-Butylphenyl)-2-[(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide

HRID 888138Notes

Reaction equation

HRID 888138 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=2F)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[NH:23]1[C:27]2=[N:28][CH:29]=[CH:30][C:31]([CH2:32][NH2:33])=[C:26]2[CH:25]=[CH:24]1>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=2[NH:33][CH2:32][C:31]2[CH:30]=[CH:29][N:28]=[C:27]3[NH:23][CH:24]=[CH:25][C:26]=23)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 21959540n-(4-Tert-butylphenyl)-2-fluoronicotinamideHCID 69263704(1h-Pyrrolo[2,3-b]pyridin-4-yl)methanamine dihydrochloride

Product 1

HCID 16225623N-(4-tert-Butylphenyl)-2-[(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide

Procedure

The titled compound was prepared from N-(4-tert-butyl-phenyl)-2-fluoro-nicotinamide and C-(1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 400 (M+H). Calc'd. for C24H25N5O—399.50.

Sources & evidence

ORD record
ord-d74bb5f8430540b2a4b845c65164aca2
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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