HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1h-Pyrrolo[2,3-b]pyridin-4-yl)methanamine dihydrochloride → (S)-2-((1H-pyrrolo[2,3-b]pyridin-4-yl)methylamino)-N-(3-(1,1,1,3,3,3-hexafluoro-2-(pyrrolidin-2-ylmethoxy)propan-2-yl)phenyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1h-Pyrrolo[2,3-b]pyridin-4-yl)methanamine dihydrochloride | HCID 69263704 | — |
| Reactant | (S)-2-(2,2,2-trifluoro-1-{3-[(2-fluoro-pyridine-3-carbonyl)-amino]-phenyl}-1-trifluoromethyl-ethoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86614215 | — |
| Product | (S)-2-((1H-pyrrolo[2,3-b]pyridin-4-yl)methylamino)-N-(3-(1,1,1,3,3,3-hexafluoro-2-(pyrrolidin-2-ylmethoxy)propan-2-yl)phenyl)nicotinamide | HCID 58941992 | — |
Reaction Steps
The titled compound was prepared from (S)-2-(2,2,2-trifluoro-1-{3-[(2-fluoro-pyridine-3-carbonyl)-amino]-phenyl}-1-trifluoromethyl-ethoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester and C-(1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride by the method described in Example 1. MS (ES+): 593 (M+H). Calc'd. for C28H26F6N6O2—592.54.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247556B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-22243f81ec764c51af78cc66789dfcbf |
| Source note | uspto-grants-2012_08 |