(1h-Pyrrolo[2,3-b]pyridin-4-yl)methanamine dihydrochloride → HCID 58942006, compound

HRID 888146Notes

Reaction equation

HRID 888146 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][O:14][C:15]([C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:31]([C:33]2[C:34](F)=[N:35][CH:36]=[CH:37][CH:38]=2)=[O:32])=[CH:26][CH:25]=1)([C:20]([F:23])([F:22])[F:21])[C:16]([F:19])([F:18])[F:17])=O)(C)(C)C.Cl.Cl.[NH:42]1[C:46]2=[N:47][CH:48]=[CH:49][C:50]([CH2:51][NH2:52])=[C:45]2[CH:44]=[CH:43]1>>[NH:42]1[C:46]2=[N:47][CH:48]=[CH:49][C:50]([CH2:51][NH:52][C:34]3[N:35]=[CH:36][CH:37]=[CH:38][C:33]=3[C:31]([NH:30][C:27]3[CH:26]=[CH:25][C:24]([C:15]([O:14][CH2:13][C@@H:9]4[CH2:10][CH2:11][CH2:12][NH:8]4)([C:16]([F:19])([F:17])[F:18])[C:20]([F:21])([F:22])[F:23])=[CH:29][CH:28]=3)=[O:32])=[C:45]2[CH:44]=[CH:43]1

Participants

3

Reactant 2

HCID 69263704(1h-Pyrrolo[2,3-b]pyridin-4-yl)methanamine dihydrochlorideHCID 86614216HCID 86614216, compound

Product 1

HCID 58942006HCID 58942006, compound

Procedure

The titled compound was prepared from (S)-2-(2,2,2-trifluoro-1-{4-[(2-fluoro-pyridine-3-carbonyl)-amino]-phenyl}-1-trifluoromethyl-ethoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester and C-(1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride by the method described in Example 1. MS (ES+): 593 (M+H). Calc'd. for C28H26F6N6O2—592.54.

Sources & evidence

ORD record
ord-85a7ef59f120403e9751815da9f9c6c0
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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