HRID888148

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2755981

1-Boc-azetidine-3-carboxylic acid

C9H15NO4

结构：CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccnc4[nH]ccc34)ccc21

HCID16225004

未命名化合物

PRODUCTS

生成物

结构：CC1(C)CN(C(=O)C2CNC2)c2cc(NC(=O)c3cccnc3NCc3ccnc4[nH]ccc34)ccc21

HCID16224423

未命名化合物

PROCEDURE

实验过程

The titled compound was prepared from N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide (Example 16) and azetidine-1,3-dicarboxylic acid 1-tert-butyl ester by the method described in Example 13. MS (ES+): 496 (M+H). Calc'd. for C28H29N7O2—495.58.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d74923f3d83b4e73abe104d8a84412b3
来源数据集: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08247556B2
来源说明: uspto-grants-2012_08

反应 SMILES

[CH3:1][C:2]1([CH3:31])[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12](=[O:30])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][C:14]=3[NH:19][CH2:20][C:21]3[CH:26]=[CH:25][N:24]=[C:23]4[NH:27][CH:28]=[CH:29][C:22]=34)=[CH:8][CH:9]=2)[NH:4][CH2:3]1.C(OC([N:39]1[CH2:42][CH:41]([C:43](O)=[O:44])[CH2:40]1)=O)(C)(C)C>>[NH:39]1[CH2:42][CH:41]([C:43]([N:4]2[C:5]3[C:10](=[CH:9][CH:8]=[C:7]([NH:11][C:12](=[O:30])[C:13]4[CH:18]=[CH:17][CH:16]=[N:15][C:14]=4[NH:19][CH2:20][C:21]4[CH:26]=[CH:25][N:24]=[C:23]5[NH:27][CH:28]=[CH:29][C:22]=45)[CH:6]=3)[C:2]([CH3:31])([CH3:1])[CH2:3]2)=[O:44])[CH2:40]1