1-Boc-Azetidine-3-carboxylic acid → HCID 16224423, compound

HRID 888148Notes

Reaction equation

HRID 888148 reaction equation
[CH3:1][C:2]1([CH3:31])[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12](=[O:30])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][C:14]=3[NH:19][CH2:20][C:21]3[CH:26]=[CH:25][N:24]=[C:23]4[NH:27][CH:28]=[CH:29][C:22]=34)=[CH:8][CH:9]=2)[NH:4][CH2:3]1.C(OC([N:39]1[CH2:42][CH:41]([C:43](O)=[O:44])[CH2:40]1)=O)(C)(C)C>>[NH:39]1[CH2:42][CH:41]([C:43]([N:4]2[C:5]3[C:10](=[CH:9][CH:8]=[C:7]([NH:11][C:12](=[O:30])[C:13]4[CH:18]=[CH:17][CH:16]=[N:15][C:14]=4[NH:19][CH2:20][C:21]4[CH:26]=[CH:25][N:24]=[C:23]5[NH:27][CH:28]=[CH:29][C:22]=45)[CH:6]=3)[C:2]([CH3:31])([CH3:1])[CH2:3]2)=[O:44])[CH2:40]1

Participants

3

Reactant 2

HCID 27559811-Boc-Azetidine-3-carboxylic acidHCID 16225004HCID 16225004, compound

Product 1

HCID 16224423HCID 16224423, compound

Procedure

The titled compound was prepared from N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide (Example 16) and azetidine-1,3-dicarboxylic acid 1-tert-butyl ester by the method described in Example 13. MS (ES+): 496 (M+H). Calc'd. for C28H29N7O2—495.58.

Sources & evidence

ORD record
ord-d74923f3d83b4e73abe104d8a84412b3
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

Loading…