(2S)-1-((tert-butoxy)carbonyl)azetidine-2-carboxylic acid → HCID 58941993, compound

HRID 888149Notes

Reaction equation

HRID 888149 reaction equation
[CH3:1][C:2]1([CH3:31])[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12](=[O:30])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][C:14]=3[NH:19][CH2:20][C:21]3[CH:26]=[CH:25][N:24]=[C:23]4[NH:27][CH:28]=[CH:29][C:22]=34)=[CH:8][CH:9]=2)[NH:4][CH2:3]1.C(OC([N:39]1[CH2:42][CH2:41][C@H:40]1[C:43](O)=[O:44])=O)(C)(C)C>>[NH:39]1[CH2:42][CH2:41][C@H:40]1[C:43]([N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([NH:11][C:12](=[O:30])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][C:14]=3[NH:19][CH2:20][C:21]3[CH:26]=[CH:25][N:24]=[C:23]4[NH:27][CH:28]=[CH:29][C:22]=34)[CH:6]=2)[C:2]([CH3:31])([CH3:1])[CH2:3]1)=[O:44]

Participants

3

Reactant 2

HCID 2734495(2S)-1-((tert-butoxy)carbonyl)azetidine-2-carboxylic acidHCID 16225004HCID 16225004, compound

Product 1

HCID 58941993HCID 58941993, compound

Procedure

The titled compound was prepared from N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide (Example 16) and (2S)-azetidine-1,2-dicarboxylic acid-1-tert-butyl ester by the method described in Example 13. MS (ES+): 496 (M+H). Calc'd. for C28H29N7O2—495.58.

Sources & evidence

ORD record
ord-47cecde231e8477c9a5a8e92d6246888
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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