HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-[(2-fluoro-pyridine-3-carbonyl)-amino]-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester → 2-[(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-6-ylmethyl)amino]-N-(4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-[(2-fluoro-pyridine-3-carbonyl)-amino]-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester | HCID 21959516 | — |
| Reactant | C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl)-methylamine dihydrochloride | HCID 69263332 | — |
| Product | 2-[(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-6-ylmethyl)amino]-N-(4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)nicotinamide | HCID 58942000 | — |
Reaction Steps
The titled compound was prepared from 7-[(2-fluoro-pyridine-3-carbonyl)-amino]-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester and C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl)-methylamine dihydrochloride by the method described in Example 1. MS (ES+): 429 (M+H). Calc'd. for C25H28N6O—428.54.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247556B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-f0fee12827e2482eb26356eb52ed78e9 |
| Source note | uspto-grants-2012_08 |