n-(4-Tert-butylphenyl)-2-fluoronicotinamide → N-(4-tert-Butylphenyl)-2-[(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-ylmethyl)amino]nicotinamide
Reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=2F)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[NH:23]1[C:27]2=[N:28][C:29]([CH2:32][NH2:33])=[CH:30][CH:31]=[C:26]2[CH2:25][CH2:24]1>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=2[NH:33][CH2:32][C:29]2[N:28]=[C:27]3[NH:23][CH2:24][CH2:25][C:26]3=[CH:31][CH:30]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]Participants
3
Procedure
The titled compound was prepared from N-(4-tert-butyl-phenyl)-2-fluoro-nicotinamide and C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 402 (M+H). Calc'd. for C24H27N5O—401.51.
Sources & evidence
- ORD record
- ord-f0830260f2b54d65bf40d68658075bd1
- Source dataset
- uspto-grants-2012_08
- Patent number
- US08247556B2
Reaction notes
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