C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride → N-(1-Acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide

HRID 888154Notes

Reaction equation

HRID 888154 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([NH:13][C:14](=[O:22])[C:15]3[CH:20]=[CH:19][CH:18]=[N:17][C:16]=3F)[CH:11]=2)[C:6]([CH3:24])([CH3:23])[CH2:5]1)(=[O:3])[CH3:2].Cl.Cl.[NH:27]1[C:31]2=[N:32][CH:33]=[CH:34][C:35]([CH2:36][NH2:37])=[C:30]2[CH2:29][CH2:28]1>>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([NH:13][C:14](=[O:22])[C:15]3[CH:20]=[CH:19][CH:18]=[N:17][C:16]=3[NH:37][CH2:36][C:35]3[CH:34]=[CH:33][N:32]=[C:31]4[NH:27][CH2:28][CH2:29][C:30]=34)[CH:11]=2)[C:6]([CH3:24])([CH3:23])[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 69263942C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochlorideHCID 69437396N-(1-acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-fluoro-nicotinamide

Product 1

HCID 16224421N-(1-Acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide

Procedure

The titled compound was prepared from N-(1-acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-fluoro-nicotinamide and C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 457 (M+H). Calc'd. for C26H28N6O2—456.55.

Sources & evidence

ORD record
ord-1cafe43ee6ea48578e170874074ceb2d
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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