Trifluoroacetic acid methylene chloride → HCID 16225626, compound

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Reaction Steps

4,4-Dimethyl-7-({2-[(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-amino]-pyridine-3-carbonyl}-amino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (123 mg, 0.23 mmol) was treated with 10 mL of 1/1 TFA/CH2Cl2 solution and stirred at RT for 1 h. The volatiles were removed under reduced pressure and the residue was purified by flash column chromatography to obtain the titled compound as a white solid. MS (ES+): 427.1 (M+H)+. Calc'd for C25H26N6O—426.22.

Provenance & Evidence