Methanol → 2-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylamino)nicotinic acid

Participants

Reaction Steps

2-Aminonicotinic acid (945 mg, 6.85 mmol) was added to a suspension of 1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (1 g, 6.85 mmol) in toluene (10 mL) under N2 atmosphere. A catalytic amount of tosyl acid was added to above and the mixture was heated to reflux for 3 h. The reaction was cooled to RT and NaBH4 was added. After stirring for 10 min., MeOH (2 ml) was added to above and the reaction was stirred for another 5 h at RT. The mixture was diluted with water and extracted with EtOAc. The aq layer was acidified using 1N HCl. The resultant precipitate was filtered and washed with AcCN affording compound as yellow solid.

Provenance & Evidence