HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 58941998, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 7-Amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one | HCID 14476478 | — |
| Reactant | 2-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylamino)nicotinic acid | HCID 69265593 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58941998 | HCID 58941998 | — |
Reaction Steps
2-((1H-Pyrrolo[2,3-b]pyridin-3-yl)methylamino)nicotinic acid (100 mg, 0.37 mmol), 7-amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one (65 mg, 0.37 mmol), TBTU (133 mg, 0.41 mmol) and DIEA (0.07 mL, 0.41 mmol) was added to DMF (1 mL). The reaction was run at RT for 24 h. The reaction was then diluted with water and the resultant precipitate was filtered and purified using flash column to afford product. MS (ES+): 441.5 (M+H). Calc'd. for C25H24N6O2—440.20.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247556B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-3cd1cb525e31407dbf28509ee92f3a0a |
| Source note | uspto-grants-2012_08 |