HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-(trifluoromethylsulfonyl)benzene → (3R)-3-methyl-1-{4-[(trifluoromethyl)sulfonyl]phenyl}piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-(trifluoromethylsulfonyl)benzene | HCID 703324 | — |
| Reactant | (3R)-1-[4-(Methanesulfonyl)phenyl]-3-methylpiperazine | HCID 26597658 | — |
| Product | (3R)-3-methyl-1-{4-[(trifluoromethyl)sulfonyl]phenyl}piperazine | HCID 11580385 | — |
Reaction Steps
The title compound was prepared following the procedure of Intermediate 26, but starting from 1-chloro-4-(trifluoromethanesulfonyl)benzene. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a pale yellow solid. M+(ESI): 309.2. HPLC (Condition A), Rt: 2.3 min (HPLC purity: 99.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247437B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-5485a5529022424594df9722d0f7b390 |
| Source note | uspto-grants-2012_08 |