1-Bromo-4-tert-butylbenzene → HCID 58487970, compound

HRID 888198Notes

Reaction equation

HRID 888198 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][NH:11][C@H:10]([CH3:14])[CH2:9]1.BrC1C=[CH:20][C:19]([C:22](C)(C)C)=[CH:18]C=1>>[C:19]([C:6]1[CH:5]=[CH:4][C:3]([N:8]2[CH2:13][CH2:12][NH:11][C@H:10]([CH3:14])[CH2:9]2)=[CH:2][CH:7]=1)([CH3:22])([CH3:20])[CH3:18]

Participants

3

Reactant 2

HCID 775951-Bromo-4-tert-butylbenzeneHCID 11600842HCID 11600842, compound

Product 1

HCID 58487970HCID 58487970, compoundYield 27%

Procedure

The title compound was prepared following the procedure of Intermediate 5 but starting from 1-bromo-4-tert-butylbenzene. Purification by chromatography using dichloromethane/methanol (8/2) as eluent afforded The title compound as a liquid (1.5 g, 27%). M+(ESI): 233.3. HPLC (Condition A), Rt: 2.8 min (HPLC purity: 96.6%).

Workup

  1. customThe title compound was prepared
  2. customPurification by chromatography

Sources & evidence

ORD record
ord-cd05cac3d20f46269e6524c2d6afec6d
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Reaction notes

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