4-Bromophenetole → (3R)-1-(4-ethoxyphenyl)-3-methylpiperazine

HRID 888199Notes

Reaction equation

HRID 888199 reaction equation
FC1C=CC([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:19][CH2:18][NH:17][C@H:16]([CH3:20])[CH2:15]3)=[CH:10][CH:9]=2)=CC=1.BrC1C=C[C:25]([O:28]CC)=[CH:24]C=1>>[CH2:25]([O:28][C:8]1[CH:9]=[CH:10][C:11]([N:14]2[CH2:19][CH2:18][NH:17][C@H:16]([CH3:20])[CH2:15]2)=[CH:12][CH:13]=1)[CH3:24]

Participants

3

Reactant 2

HCID 685234-BromophenetoleHCID 58487952HCID 58487952, compound

Product 1

HCID 58487956(3R)-1-(4-ethoxyphenyl)-3-methylpiperazine

Procedure

The title compound was prepared following the procedure of Intermediate 22 but starting from 1-bromo-4-ethoxybenzene. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a brown solid. M+(ESI): 221.3. HPLC (Condition A), Rt: 1.5 min (HPLC purity: 97.6%).

Workup

  1. customThe title compound was prepared
  2. customPurification by flash chromatography (CHCl3/MeOH)

Sources & evidence

ORD record
ord-139f822ec87f4e5baa83adf6bd917007
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Reaction notes

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