HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(5-(2-Thienyl)-1,2,4-oxadiazol-3-yl)piperazine, dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(5-(2-thienyl)-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate | HCID 58487964 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(5-(2-Thienyl)-1,2,4-oxadiazol-3-yl)piperazine, dihydrochloride | HCID 131729127 | 78% |
Reaction Steps
A solution of tert-butyl 4-(5-(2-thienyl)-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate (2.2 g) in 2M HCl in Et2O (50 mL) was stirred at RT for 6 hours. The solvent was removed under vacuum to give 1.6 g (78%) of The title compound as a solid. TLC-CHCl3/MeOH (8/2): Rf=0.2. HPLC purity>98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247437B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-4bb5bf313bd344029e9822786c101895 |
| Source note | uspto-grants-2012_08 |