HCID 59553048, compound → HCID 59553047, compound

Participants

Reaction Steps

6-(2-Nitro-phenyl)-3-[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazole (54 g, 165 mmol) was dissolved in ethanol (2.0 L). Pd/C (10%, 20 g) was added, and the flask was evacuated and backfilled with H2. The reaction mixture was stirred under H2 at room temperature (2 days). The reaction mixture was then passed through a silica gel pad, and the filtrate was concentrated in vacuo to give a yellow solid. The solid was washed with ethanol to give 2-(3-[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenylamine as a yellow solid (46 g, 94% yield).

Provenance & Evidence