Methane → HCID 178495389, compound

Participants

Reaction Conditions

Reaction Steps

Rabeprazole (10 g) was suspended in 20 ml water and sodium hydroxide solution (1.11 g sodium hydroxide dissolved in 10 ml water) was added at 25-30° C. Reaction mass was stirred for 30 minutes at 25-30° C. Added activated charcoal (1.0 g) and stirred for 30 minutes at 25-30° C. Filtered and washed charcoal bed with water (10 ml). Added 30 ml ethanol to filtrate and distilled out till get oily residue under reduced pressure at 30-35° C. Again added 30 ml ethanol to the oily residue and distilled out completely under reduced pressure at 35° C. To the residue added 100 ml diisopropyl ether and stirred at 25-30° C. for two hours. Filtered product under nitrogen atmosphere and washed with 20 ml diisopropyl ether. Dried under vacuum at 50° C. for 20-24 hours to obtain amorphous Rabeprazole sodium.

Provenance & Evidence