Ethyl Acetate → HCID 16047991, compound

Participants

Reaction Steps

After 156 g of ethyl acetate and 100 g of water were added into 39 g of (R)-3-benzyloxypyrrolidine hydrochloride which had been obtained separately and the mixture was stirred for a while, an organic layer was separated. After 156 g of ethyl acetate was added to the resultant aqueous layer and cooled by ice, 24 g of 30% aqueous solution of sodium hydroxide was dropped. After stirring for a while and separating an aqueous layer, an organic layer was washed with 20 g of water. The resultant organic layer was concentrated and dried under reduced pressure, thereby obtaining 33 g (purity 86.6%) of a concentrate of (R)-3-benzyloxypyrrolidine. An amount of (R)-3-hydroxypyrrolidine with respect to (R)-3-benzyloxypyrrolidine was reduced from 0.84 wt % to 0.12 wt % by the above operations.

Provenance & Evidence