Trifluoroacetic acid → 3-(5-Methylpyridin-2-yl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzoic acid

Participants

Reaction Steps

To a 0° C. DCM (6.8 mL) solution of tert-butyl 3-(5-methylpyridin-2-yl)-5-[92,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzoate (0.6 g, 1.38 mmol) from step C was added trifluoroacetic acid (6.9 mL). The mixture was warmed to rt over 2 h and concentrated to dryness to give a gummy solid. The crude title compound was used in step E without further purification. LC-MS (M+H)=380.1

Provenance & Evidence