Lawesson's reagent → HCID 86646757, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 3-[(methylamino)carbonyl]-5-(5-methylpyridin-2-yl)benzoate (1.0 g, 3.06 mmol) in dichloroethane (8 mL) was added 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (0.68 g, 1.69 mmol). The reaction mixture was heated to 50° C. After 3 h, saturated aqueous sodium bicarbonate was added and the mixture was extracted with dichloromethane (3×). The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% dichloromethane→90% dichloromethane/methanol) gave the title compound. MS 343.0 (M+1).

Provenance & Evidence