HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 3-(1-amino-2,2,2-trifluoroethyl)-5-(5-methylpyridin-2-yl)benzoate | HCID 68496539 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetate | HCID 84468 | — |
| Product | 3-(1-Amino-2,2,2-trifluoroethyl)-5-(5-methylpyridin-2-yl)benzoic acid | HCID 68502325 | — |
Reaction Steps
To a solution of tert-butyl 3-(1-amino-2,2,2-trifluoroethyl)-5-(5-methylpyridin-2-yl)benzoate (30.0 mg, 0.08 mmol) in dichloromethane (0.5 mL) was added trifluoroacetic acid (0.3 mL). The mixture was stirred at ambient temperature. After 5 h, the mixture was concentrated to dryness to give the trifluoracetate salt of the title compound (35 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247401B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-5979bd0305a240f2883a70944b337ef1 |
| Source note | uspto-grants-2012_08 |