Potassium Carbonate → [3-(4-Chloro-2-formyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	5-Chloro-2-fluorobenzaldehyde	HCID 2773586	—
Reactant	Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate	HCID 5324706	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	[3-(4-Chloro-2-formyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester	HCID 58237578	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

(3-Hydroxy-4-methoxy-phenyl)-acetic acid ethyl ester (0.75 g, 4.8 mmol), 5-chloro-2-fluorobenzaldehyde (1.0 g, 4.8 mmol), and potassium carbonate (1.0 g, 7.5 mmol) were combined in 1,4-dioxane (30 mL) and heated to 100° C. for 3 days. After work-up, the crude material was purified by silica gel chromatography (0-20% EtOAc in hexanes) to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08247602B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-1491a8c6f40246b3bfbc5b3114a333f1
Source note	uspto-grants-2012_08