HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanethiol → [3-(4-Bromo-2-isopropylsulfanylmethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanethiol | HCID 6364 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | [3-(4-Bromo-2-bromomethyl-phenoxy)-4-methoxy-phenyl]acetic acid ethyl ester | HCID 58237498 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [3-(4-Bromo-2-isopropylsulfanylmethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester | HCID 58372820 | — |
Reaction Steps
[3-(4-Bromo-2-bromomethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester (0.4 g, 0.87 mmol) and 2-propanethiol (0.08 g, 1.0 mmol) were combined in 1,4-dioxane (20 mL). Sodium hydride (60% in mineral oil; 0.04 g, 1.0 mmol) was added, and the reaction was stirred at room temperature for 20 minutes. The mixture was worked up to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247602B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-9af4d39344954e2a97b5c28b5e66e1ca |
| Source note | uspto-grants-2012_08 |