HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 888498Generated: October 30, 2026
Benzyl Alcohol → 1-(Benzyloxy)-3-bromo-5-chlorobenzene
https://huagongshe.com/reaction/888498
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Bromo-3-chloro-5-fluorobenzene | HCID 2736223 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-(Benzyloxy)-3-bromo-5-chlorobenzene | HCID 53217008 | — |
Reaction Steps
To 1-bromo-3-chloro-5-fluorobenzene (25 g, 112 mmol) and benzyl alcohol (25 mL, 239 mmol) in NMP (200 mL) at room temperature was added sodium hydride (60% in mineral oil; 10.5 g, 263 mmol), and the reaction was heated to 120° C. for 10 hours. The mixture was acidified with 10% aqueous HCl and extracted with EtOAc to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08247602B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-fac2c72e136a4636a91b4f91cf675292 |
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| Source note | uspto-grants-2012_08 |
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