(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester → (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

関与物質

反応条件

反応手順

(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester (1.7 g, 5.6 mmol) was dissolved in EtOH (30 mL) and degassed with N2. 5% Palladium on carbon (1 g) was added, and the reaction was purged with H2 and then stirred under an H2 balloon at 50° C. overnight. The mixture was filtered and concentrated to give (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester.

情報源と証拠