Hydrochloric Acid → HCID 59378430, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3.0 g of 3-(trifluoromethyl)pentyl methanesulfonate and 2.6 g of (3,3,3-trifluoropropylsulfonyl)acetonitrile in 50 ml of dimethyl sulfoxide was added 1.8 g of potassium carbonate at room temperature, heated to 60° C. and then stirred at the same temperature for 3 days. The reaction mixture was allowed to stand to cool to nearly room temperature. To the reaction mixture was added 10% hydrochloric acid, and then extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The obtained residue was subjected to silica gel chromatography to obtain 3.00 g of 5-(trifluoromethyl)-2-(3,3,3-trifluoropropylsulfonyl)heptanenitrile (hereinafter referred to as the present compound (14)).

Provenance & Evidence