Hydrochloric Acid → HCID 59378448, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5.0 g of 4-methyl-3-(trifluoromethyl)pentyl methanesulfonate and 4.7 g of methyl (3,3,3-trifluoropropylsulfonyl)acetate in 100 ml of dimethyl sulfoxide was added 2.8 g of potassium carbonate at room temperature. The reaction mixture was heated to 60° C., stirred at the same temperature for 3 days and then allowed to stand to cool to nearly room temperature. To the reaction mixture was added 10% hydrochloric acid, and then extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The obtained residue was subjected to silica gel chromatography to obtain 4.10 g of methyl 6-methyl-5-(trifluoromethyl)-2-(3,3,3-trifluoropropylsulfonyl)heptanoate (hereinafter referred to as the present compound (18)).

Provenance & Evidence