Hydrochloric Acid → HCID 59378440, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3.0 g of 3-(trifluoromethyl)-hexyl methanesulfonate and 2.8 g of methyl (3,3,3-trifluoropropylsulfonyl)acetate in 50 ml of dimethyl sulfoxide was added 1.7 g of potassium carbonate at room temperature. The reaction mixture was heated to 60° C., stirred at the same temperature for 2 days, and then allowed to stand to cool to nearly room temperature. To the reaction mixture was added 10% hydrochloric acid, and then extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The obtained residue was subjected to silica gel chromatography to obtain 1.90 g of methyl 5-(trifluoromethyl)-2-(3,3,3-trifluoropropylsulfonyl)octanoate (hereinafter referred to as the present compound (21)).

Provenance & Evidence