Hydrochloric Acid → HCID 86642974, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.0 g of 4,4,4-trifluoro-3-methylthio-butyl methanesulfonate and 0.8 g of (3,3,3-trifluoropropylsulfonyl)acetonitrile in 30 ml of dimethyl sulfoxide was added 0.5 g of potassium carbonate at room temperature, heated to 60° C. and then stirred at the same temperature for 2 days. The reaction mixture was allowed to stand to cool to nearly room temperature. To the reaction mixture was added 10% hydrochloric acid, and then extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The obtained residue was subjected to silica gel chromatography to obtain 0.49 g of 6,6,6-trifluoro-5-methylthio-2-(3,3,3-trifluoropropylsulfonyl)hexanenitrile (hereinafter referred to as the present compound (30)).

Provenance & Evidence