Hydrochloric Acid → HCID 59378455, compound

Participants

Reaction Steps

The solution of 3-(trifluoromethyl)-1-pentanol in diethyl ether obtained in Step 4 and 26.8 g of p-toluenesulfonyl chloride were dissolved in 300 ml of tetrahydrofuran. To the solution was added dropwise 20 ml of triethylamine at room temperature, and stirred at the same temperature for 4 days. To the reaction mixture was added 10% hydrochloric acid, and then extracted with ethyl acetate. The organic layer was sequentially washed with 10% hydrochloric acid and a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel chromatography to obtain 18.4 g of 3-trifluoromethyl-pentyl p-toluenesulfonate.

Provenance & Evidence