4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 3-(4-Chloro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine

Participants

Role	Name	HCID	Charge
Reactant	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	HCID 2774010	—
Reactant	3-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propylamine	HCID 57691409	—
Product	3-(4-Chloro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine	HCID 11771347	—

Reaction Steps

3-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propylamine was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole following the procedure set out in Example 1 to give the title compound. LC/MS: (PS-B3) Rt 2.54 [M+H]+ 312.04. 1H NMR (Me-d3-OD) δ 2.39 (2H, m), 2.84 (2H, t), 4.06 (1H, t), 7.27-7.33 (6H, m), 7.54 (2H, d), 7.91 (2H, s).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08247576B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-df325bcfa4a44c8987899c5eff2544c2
Source note	uspto-grants-2012_08