Ammonia → 2-(4-Chloro-phenyl)-N-methyl-2-[4-(1H-pyrazol-4-yl)-phenyl]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	Methylamine	HCID 6329	—
Reactant	Bis(4-chlorophenyl)acetic acid	HCID 6730	—
Reactant	3-(4-Chloro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine	HCID 11771347	—
Product	2-(4-Chloro-phenyl)-N-methyl-2-[4-(1H-pyrazol-4-yl)-phenyl]-acetamide	HCID 11359296	—

Reaction Steps

By following the procedure described in Example 12A followed by 12C but substituting 3-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propionic acid for Bis-(4-chloro-phenyl)-acetic acid and ammonia for methyl amine, the title compound was obtained. LC/MS (PS-A2): Rt 2.64 [M+H]+ 326. 1H NMR (Me-d3-OD) δ 2.79 (3H, s), 4.94, (1H, br s), 7.26-7.35 (6H, m), 7.55-7.57 (2H, m), 7.96 (2H, br s)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08247576B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-5136d5ca8a6e4cd392d8857559611a52
Source note	uspto-grants-2012_08