HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 4-[4-(2-Methoxy-ethoxy)-phenyl]-4-[4-(1H-pyrazol-4-yl)-phenyl]-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2774010 | — |
| Reactant | HCID 59331944 | HCID 59331944 | — |
| Catalyst | Palladium--triphenylphosphane (1/1) | HCID 15220664 | — |
| Product | 4-[4-(2-Methoxy-ethoxy)-phenyl]-4-[4-(1H-pyrazol-4-yl)-phenyl]-piperidine | HCID 11257423 | — |
Reaction Steps
4-(4-Bromo-phenyl)-4-[4-(2-methoxy-ethoxy)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-pyrazole following the procedure set out in Example 1, substituting tetrads triphenylphosphine palladium (0) as catalyst, the title compound was obtained. LC/MS: (PS-A2)Rt 3.27 [M+H]+ 478.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247576B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-071124b357fe47f78dbbcbe7c4cfbd96 |
| Source note | uspto-grants-2012_08 |