HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Methyl-1-trityl-1H-pyrazol-4-yl)boronic acid → 4-(4-Chloro-phenyl)-4-[4-(3-methyl-1-trityl-1H-pyrazol-4-yl)-phenyl]-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Methyl-1-trityl-1H-pyrazol-4-yl)boronic acid | HCID 22031628 | — |
| Reactant | 4-(4-Bromophenyl)-4-(4-chlorophenyl)piperidine--hydrogen chloride (1/1) | HCID 67235252 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Product | 4-(4-Chloro-phenyl)-4-[4-(3-methyl-1-trityl-1H-pyrazol-4-yl)-phenyl]-piperidine | HCID 67235134 | — |
Reaction Steps
4-(4-bromo-phenyl)-4-(4-chloro-phenyl)-piperidine hydrochloride was reacted with 3-methyl-1-trityl-1H-pyrazole-4-boronic acid* following the procedure set out in Example 1, but using tetrakis(triphenylphosphine) palladium (0) as the catalyst to give the title compound. LC/MS: (PS-B3) Rt 2.78 min [M+H]+ 594.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247576B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-18bd33abba894543bb24b866e9c8b551 |
| Source note | uspto-grants-2012_08 |