HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydroquinoline → 2-[5-(3,4-Dihydro-2H-quinolin-1-yl)-4'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| Reactant | HCID 59004769 | HCID 59004769 | — |
| Product | 2-[5-(3,4-Dihydro-2H-quinolin-1-yl)-4'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester | HCID 57666604 | 25% |
Reaction Steps
The title compound was prepared in 25% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester and 1,2,3,4-tetrahydroquinoline under the conditions described in Example 24, steps (a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247610B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-11edbc12b41246a09afe1b56e13c56ea |
| Source note | uspto-grants-2012_08 |