HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide → 4-Methyl-1-(4-(trifluoromethyl)phenyl)pentan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide | HCID 14069348 | — |
| Reactant | HCID 178418529 | HCID 178418529 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Methyl-1-(4-(trifluoromethyl)phenyl)pentan-1-one | HCID 46941396 | 77% |
Reaction Steps
With the similar conditions of Example 29, steps (a) and (c), reaction of N-Methoxy-N-methyl-4-trifluoromethyl-benzamide, compound 31 a, with 3-methyl-1-butyl magnesium bromide, compound 29a, in THF gave the title compound in 77% yield; Calcd MW 244.26. Found MH+ 245.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247610B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-42b29be0db1342bfaf79a46419c91ce7 |
| Source note | uspto-grants-2012_08 |