3-Methylbutanal → HCID 57666616, compound

HRID 888664Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=2)[CH:12]=[C:13]([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[CH:38](=O)[CH2:39][CH:40]([CH3:42])[CH3:41]>>[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:27]2[CH:28]=[CH:29][C:30]([C:33]([F:34])([F:35])[F:36])=[CH:31][CH:32]=2)[CH:12]=[C:13]([N:15]([CH2:38][CH2:39][CH:40]([CH3:42])[CH3:41])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:25])([F:24])[F:26])=[CH:19][CH:18]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

Reactant 2

HCID 115523-Methylbutanal

HCID 76587699HCID 76587699, compound

Product 1

HCID 57666616HCID 57666616, compound

Procedure

Following the procedure of Example 39, step (a), reaction of 4-Methyl-2-[4′-trifluoromethyl-5-(4-trifluoromethyl-benzylamino)-biphenyl-3-yl]-pentanoic acid methyl ester, compound 44a with isovaleraldehyde gave the title compound; Calcd.MW 593.66. Found MH+ 594.3.

Sources & evidence

ORD record: ord-bc7c6aa849c14b05ad6b3bdeadc1c37d
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08247610B2

Reaction notes

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