3-Methylbutanal → HCID 76587704, compound

HRID 888665Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:35])[CH:4]([C:9]1[CH:10]=[C:11]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)[CH:12]=[C:13]([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[CH:36](=O)[CH2:37][CH:38]([CH3:40])[CH3:39]>>[CH3:1][O:2][C:3](=[O:35])[CH:4]([C:9]1[CH:10]=[C:11]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)[CH:12]=[C:13]([N:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=2)[CH2:36][CH2:37][CH:38]([CH3:40])[CH3:39])[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

Reactant 2

HCID 115523-Methylbutanal

HCID 68734293HCID 68734293, compound

Product 1

HCID 76587704HCID 76587704, compound

Procedure

Following the procedure of Example 39, step (a), reaction of 2-[5-(4-Cyano-benzylamino)-4′-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester, compound 47a with isovaleraldehyde gave the title compound; Calcd. MW 550.67. Found MH+ 551.4.

Sources & evidence

ORD record: ord-81a01f9df02542d6b0e1076a0a330f94
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08247610B2

Reaction notes

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